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What is the rebuild hair program review? Abstract Alopecia hair loss occurs in some nonhuman primates housed in captivity and is of concern to colony managers and veterinarians. Here we review the characteristics, potential causes, and treatments for this condition.
Although we focus on nonhuman primates, relevant research on other mammalian species is discussed also, due to the relative paucity of studies on alopecia in the primate literature. We first discuss the cycle of hair growth and explain how this cycle can be disrupted to produce alopecia. Numerous factors may be related to hair loss and range from naturally occurring processes for example, seasonality, aging to various biologic dysfunctions, including vitamin and mineral imbalances, endocrine disorders, immunologic diseases, and genetic mutations.
We also address bacterial and fungal infections, infestation by parasites, and atopic dermatitis as possible causes of alopecia. Finally, we examine the role of psychogenic factors, such as stress. Depending on the presumed cause of the hair loss, various treatment strategies can be pursued. Alopecia in nonhuman primates is a multifaceted disorder with many potential sources. For this reason, appropriate testing for various disease conditions should be completed before alopecia is considered to be related to stress.
Abbreviations: VDR, vitamin D receptor Hair loss alopecia is a complex phenomenon that is not fully understood either in human or nonhuman primates.
Hair loss can occur as the result of a congenital or genetic disorder, or it can develop during the lifetime of the animal. Hair loss occurring throughout life can be further divided into inflammatory and noninflammatory types.
In this article, we focus on alopecia in nonhuman primates. We also will refer to humans and other mammals, given that mechanisms of hair loss and potential treatments for this disorder have been studied infrequently in nonhuman primates. Patterns of hair loss can be categorized in various ways, and several different types of scoring systems have been developed for both animals and humans.
Using rhesus monkeys as an example, typical patterns of hair loss include: 1 substantial whole-body hair loss balding on the head, back, legs, and arms ; 2 substantial hair thinning in various body regions that is, hair is present but sparse ; 3 extensive patches of bare skin, often bilateral in presentation, interspersed with normal hair; and 4 1 or 2 small patches of bare skin on normally haired monkeys.
A third dimension of hair loss is duration: hair loss can be short-term less than 3 mo , long-term lasting anywhere from 3 to 24 mo , or permanent. In the following paragraphs, we consider the typical hair cycle and various factors that can disrupt this cycle to cause loss of hair.
The Hair Cycle The hair follicle possesses a unique ability to regenerate itself throughout the life of the organism. Hair growth occurs in a series of stages, starting with the anagen or growth phase.
During this period, cell division in the matrix of the hair bulb produces keratinocytes, which form the various layers of the individual hair shaft. Melanocytes in the hair bulb provide the keratinocytes with pigment. After the hair reaches a certain length, which varies depending on body region, it enters the catagen or degradation phase, when cell division and pigmentation cease.
During the telogen or resting phase, a new follicle appears below the original follicle, the hair shaft grows back into the original follicle, and the previous hair shaft is shed.
It is unclear whether the hair is lost simply as a result of the new hair shaft's upward trajectory or whether there is a separate active shedding exogen stage.
Some forms of hair loss are associated with excessive shedding of hair, a prolongation of the telogen phase commonly referred to as telogen effluvium.